Patent 7883853 was granted and assigned to Sunnybrook Health Sciences Centre on February, 2011 by the United States Patent and Trademark Office.
A method is provided for screening a subject for hepatocellular carcinoma by determining the level of glypican-3 (GPC3) in a body fluid sample from the subject. A further method is provided for diagnosing hepatocellular carcinoma by detecting GPC3 in a liver tissue sample. Also provided are antibodies which bind specifically to GPC3.