Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Simon Topell0
Susanne Richter0
Date of Patent
February 15, 2011
0Patent Application Number
119225910
Date Filed
June 20, 2006
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first chromatography using an anion exchange matrix, a second chromatography using hydroxyapatite and, optionally, a size exclusion chromatography. VLP preparations obtained by the process of the invention are essentially free of endotoxin contaminations.
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