Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
February 15, 2011
Patent Application Number
12092999
Date Filed
November 9, 2006
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides phosphoramidate derivatives of a furanosyluracil analog, FAU, that can effectively deliver FAU monophosphate, or a derivative thereof, intracellularly. FAU-Phosphoramidate diesters can bypass the first step of phosphorylation and be activated intracellularly so as to be converted to nucleoside monophosphates. This results in improved formation of nucleoside triphosphates, and higher incorporation into DNA. The compounds of the invention can be used to treat cancer.
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