Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Dennis M. Klinman0
Ihsan Gursel0
Mayda Gursel0
Date of Patent
February 22, 2011
0Patent Application Number
120650850
Date Filed
August 28, 2006
0Patent Citations Received
Patent Primary Examiner
Patent abstract
It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
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