Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Howland Shaw Warren, Jr.0
Huan Yang0
Kevin J. Tracey0
Mitchell P. Fink0
Date of Patent
March 1, 2011
0Patent Application Number
119019630
Date Filed
September 19, 2007
0Patent Primary Examiner
Patent abstract
Compositions and methods are disclosed for inhibiting the release of a proinflammatory cytokine from a vertebrate cell, and for inhibiting an inflammatory cytokine cascade in a patient. The compositions comprise a vertebrate HMGB A box, and an antibody preparation that specifically binds to a vertebrate HMGB B box. The methods comprise treating a cell or a patient with sufficient amounts of the composition to inhibit the release of the proinflammatory cytokine, or to inhibit the inflammatory cytokine cascade.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
