Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ye Edward Tian0
Adnan M. M. Mjalli0
Jeffrey C. Webster0
Robert Rothlein0
Date of Patent
March 8, 2011
0Patent Application Number
111970380
Date Filed
August 3, 2005
0Patent Primary Examiner
Patent abstract
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
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