Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ian Hector Frazer0
Date of Patent
March 8, 2011
0Patent Application Number
110779390
Date Filed
March 11, 2005
0Patent Primary Examiner
Patent abstract
The present invention discloses a method for modulating the production of a protein from a polynucleotide in a CHO cell by replacing at least one codon of the polynucleotide with a synonymous codon that has a higher or lower translation efficiency in the CHO cell than the codon it replaces, or by introducing into the CHO cell a polynucleotide that codes for an iso-tRNA which limits the rate of production of the polypeptide and which corresponds to a codon of the first polynucleotide. The present invention also discloses the use of a protein-encoding polynucleotide whose codon composition has been modified for enhanced production of the protein in CHO cells.
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