The desander (10) for positioning downhole includes a generally tubular desander body (16) and a generally sleeve-shaped vortex body (39, 94). The desander with a seal or packer may be positioned in a well below the casing perforations. The desander with an ESP may be used with gas separator (60), which may include a seal (24) for positioning above the producing formation. The separator (60) may be used independent of the desander for some applications.