A fluid system component is provided that includes first and second elements configured to be removably engaged with each other and defining a fluid passageway when engaged. The first element defines at least one groove. Correspondingly, the second element includes at least one engagement member configured and arranged to be received in, and travel along, a corresponding groove. The presence of a line pressure in the passageway substantially forecloses disengagement of the first and second elements until the fluid pressure in the fluid passageway has decreased to a predetermined magnitude. A handling and locking mechanism for selectively securing the second element relative to the first element is included. The locking mechanism includes a movable pin controlled by a pin handle adjacent a collar handle. The pin and collar handles can be gripped simultaneously by the same hand of a user to release the first element relative to the second element.