Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Craig Morrell0
Kenji Matsushita0
Charles Lowenstein0
Date of Patent
March 22, 2011
0Patent Application Number
105536860
Date Filed
April 15, 2004
0Patent Primary Examiner
Patent abstract
Methods and compositions for blocking exocytosis by inhibition of proteins that regulate exocytosis, such as N-ethylmaleimide Sensitive Factor (NSF), are provided. The compositions include multidomain fusion peptides containing a domain that causes the fusion peptide to cross the cellular membrane (e.g. a domain from the TAT protein of HIV) and a domain that inhibits NSF (e.g. a domain of NSF). Administration of the fusion peptide promotes anticoagulation, attenuates thrombosis, and decreases heart attack severity.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
