Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Wolfgang W. Deppert0
Irene Dornreiter0
Date of Patent
March 22, 2011
Patent Application Number
11236014
Date Filed
September 27, 2005
Patent Primary Examiner
Patent abstract
Novel human p53 splice variant displaying differential transcriptional activity Described is a nucleic acid molecule encoding a p53 variant characterized in that it is capable of transactivating the p21- and 14-3-3σ-promoter but not the mdm2-, bax- and PIG3-promoter. Preferably, in said p53 variant exon 7, exon 8 and/or exon 9 are partially or entirely deleted. Finally, means for inhibiting the activity of this p53 variant are described which are useful for the therapy of cancer.
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