A method of adjusting sensitivity of signal interpretation includes the steps of: continuously receiving an input signal; setting a sampling parameter; sampling the input signal according to the sampling parameter to obtain a plurality of sampling signals; judging whether the sampling signals are the same or not; generating a first control signal according to the sampling signals if the sampling signals are the same; and generating a second control signal according to the input signal if the sampling signals are not the same. A device of adjusting the sensitivity of signal interpretation is also disclosed.