US Patent 7919279 Methods and compositions for KIR genotyping
Patent 7919279 was granted and assigned to CHILDREN'S HOSPITAL & RESEARCH CENTER AT OAKLAND on April, 2011 by the United States Patent and Trademark Office.
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The present invention provides methods for single nucleotide polymorphism (SNP)-based killer cell immunoglobulin-like receptor (KIR) gene cluster genotyping using the matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer. In general, the methods involve amplifying a plurality of target sequences of a plurality of KIR genes, and detecting the presence or absence of a plurality of single SNPs of the plurality of KIR genes by MALDI-TOF mass spectrometry. The invention also features compositions, including arrays of capture primers and optionally extension primers on a substrate surface, and kits, for use in the methods of the invention.
US Patent 07919279 Methods and compositions for KIR genotyping US Patent 7919279 Methods and compositions for KIR genotyping
US Patent 07919279 Methods and compositions for KIR genotyping
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