Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Hengbin Wang0
Yi Zhang0
Date of Patent
April 12, 2011
0Patent Application Number
119156100
Date Filed
June 1, 2006
0Patent Primary Examiner
Patent abstract
The present invention provides a native or reconstituted complex comprising Bmi1 and/or Ring1 and/or Ring2, wherein the complex has ubiquitin E3 ligase activity. Optionally, the complex further comprises HPH2 and/or HPC3. Also disclosed are methods of producing the reconstituted complex, methods of identifying compounds that modulate the ubiquitin E3 ligase activity of the native or reconstituted complex, and methods of identifying candidate compounds for treating cancer. Kits for determining modulation of protein ubiquitination and/or for ubiquitinating a target substrate are further provided.
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