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US Patent 7931903 Internalizing anti-CD74 antibodies and methods of use

Patent 7931903 was granted and assigned to IMMUNOMEDICS, INC. on April, 2011 by the United States Patent and Trademark Office.

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Patent abstract

The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, which is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies, other malignancies in which the cells are reactive with CD74, and autoimmune diseases, and methods of treatment and diagnosis.

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