Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
April 26, 2011
Patent Application Number
12010048
Date Filed
January 18, 2008
Patent Citations Received
Patent Primary Examiner
Patent abstract
Provided are methods of isolating and proliferating antigen-specific CD8+ T cells using anti-4-1BB antibodies. The methods of isolating and proliferating CD8+ T cells may yield cells at a higher recovery rate than a conventional isolation method, and the isolation method using humanized anti-4-1BB antibodies may also yield cells at a high recovery rate. Further, in cell culture, cells may be grown at a high proliferation rate. The antigen-specific CD8+ T cells yielded according to the isolation and proliferation methods may be used to treat cancer without any side-effects.
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