A hand-held electric sealer with a detachable sealing module includes a casing, a sealing module, and a press bar. The casing includes, among others, a front contact holder which is provided with an engagement hole. The sealing module includes, among others, a lower cover from underside of which extended an engagement piece. The engagement piece of the sealing module can be engaged with the engagement hole of the casing, such that the sealing module can be conveniently attached to, or detached from, the casing, and that replacement of a damaged sealing module can be readily achieved. In addition, for the sealing module dual heating wires may also be employed so as to obtain a desirable sealing effect to plastic bags.