A medical guide wire includes a core wire having a distal portion, and a cover portion formed of a resin for covering at least the distal portion of the core wire, and is provided with a distal shape portion having a curved portion, wherein the distal portion of the core wire includes a tapered portion continuously varied in outside diameter, and a distal flexible portion provided on the distal side of the tapered portion, and the wire diameter variation rate at the tapered portion is 40 to 55%.