Patent 7943325 was granted and assigned to Prince Henry's Institute of Medical Research on May, 2011 by the United States Patent and Trademark Office.
The present invention relates to a method of diagnosing an infertility condition in a human female subject, the method comprising detecting pregnancy-related serine protease (PRSP) protein in a test sample taken from said subject at between 7 and 20 weeks into pregnancy; detecting PRSP protein in a test sample from a fertile control mammal taken within the same period; and comparing the PRSP protein in the test sample with the PRSP protein detected in the control sample, wherein a change in PRSP protein in the sample compared to the control sample is indicative of an infertility condition.