Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michela Alessandra Denti0
Alessandro Rosa0
Irene Bozzoni0
Date of Patent
May 24, 2011
0Patent Application Number
105640200
Date Filed
July 9, 2004
0Patent Primary Examiner
Patent abstract
The authors describe an expression system for the correct, stable and effective expression in mammalian cells of a siRNA comprising: a) a polymerase II RNA-dependent promoter derived from the U1 RNA gene; downstream from the sequence b) suitable restriction sites for the cloning of the sequence transcribing the pre-siRNA; downstream from these sites c) sequences derived from the sequences at 3′ of the gene for U1 snRNA that are necessary and sufficient for the correct formation of 3′ of the presiRNA.
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