A plastic specimen bag (10) includes a front wall (20) and a rear wall (22) that are joined together to define a containment portion (32) having a bottom (24), side edges (26, 28), and a top opening (30). The plastic specimen bag (10) further includes a first closure (C1) located between the bottom (24) and the top opening (30) for selectively closing the containment portion (32). To facilitate opening the specimen bag (10), the specimen bag (10) includes a first grip enhancing profile (50) and a second grip enhancing profile (52) that are formed in the front wall (20) and spaced apart from one another to define a tear area (54) therebetween. The tear area (54) is located between the closure (C1) and the bottom (24).