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US Patent 7951360 Mutant interleukin-2 (IL-2) polypeptides

Patent 7951360 was granted and assigned to Massachusetts Institute of Technology on May, 2011 by the United States Patent and Trademark Office.

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Patent abstract

The present invention relates to IL-2 mutants with increased affinity for the IL-2 alpha-receptor subunit (IL-2Rα). The invention thus includes IL-2 mutants with improved biological potency. The invention also includes methods for directed evolution of IL-2α using yeast surface display to generate mutants with increased affinity for IL-2Rα.

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