Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
May 31, 2011
Patent Application Number
11985601
Date Filed
November 15, 2007
Patent Primary Examiner
Patent abstract
The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor; as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.
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