US Patent 7964190 Methods and compositions for decreasing T-cell activity
Patent 7964190 was granted and assigned to Human Genome Sciences on June, 2011 by the United States Patent and Trademark Office.
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The present invention relates to a novel member of the TNF-Ligand superfamily. More specifically, isolated nucleic acid molecules are provided encoding a human Apoptosis Inducing Molecule II (AIM II). AIM II polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of AIM II activity. Also provided are therapeutic methods for treating lymphadenopathy, aberrant bone development, autoimmune and other immune system diseases, graft versus host disease, rheumatoid arthritis, osteoarthritis and to inhibit neoplasia, such as tumor cell growth.
US Patent 07964190 Methods and compositions for decreasing T-cell activity US Patent 7964190 Methods and compositions for decreasing T-cell activity
US Patent 07964190 Methods and compositions for decreasing T-cell activity
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