Is a
Patent attributes
Current Assignee
0
Patent Jurisdiction
Patent Number
Patent Inventor Names
Stanley J. Korsmeyer0
Emily H. Y. Cheng0
James J. D. Hsieh0
Date of Patent
June 21, 2011
0Patent Application Number
118513010
Date Filed
September 6, 2007
0Patent Primary Examiner
Patent abstract
A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.
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