US Patent 7968281 Methods of modulating SMYD3 for treatment of cancer
Patent 7968281 was granted and assigned to OncoTherapy Science, Inc. on June, 2011 by the United States Patent and Trademark Office.
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Patent abstract
The present invention features a method for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of retinoblastoma by SMYD3. The invention further provides a method or pharmaceutical composition for prevention or treating of colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified. N-terminal truncated forms of SMYD3 (alias ZNFN3A1) have higher methylating activity. Lys 824 is a preferred methylation site on the RB1 protein for SMYD3.
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US Patent 07968281 Methods of modulating SMYD3 for treatment of cancer US Patent 7968281 Methods of modulating SMYD3 for treatment of cancer
Infobox
Patent Number
0796828112
Patent Number
796828112
1
Type: Web page
Patent. https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/79682812
Type: Web page
Patent. https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7968281Edits on 25 Apr, 2023
Golden AI
Infobox
Is a
Current Assignee
Patent Jurisdiction
Patent Number
079682811
Date of Patent
June 28, 2011
1Patent Application Number
119128601
Date Filed
June 23, 2006
1Patent Primary Examiner
1
Type: Web page
Patent. https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7968281Edits on 26 Sep, 2022
Golden AI
Infobox
Is a
Current Assignee
Patent Jurisdiction
Patent Number
079682811
Date of Patent
June 28, 2011
1Patent Application Number
119128601
Date Filed
June 23, 2006
1Patent Primary Examiner
1
Type: Web page
Patent. https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7968281Edits on 8 Dec, 2021
Golden AI
Edits made to:
Infobox (+8 properties)
US Patent 07968281 Methods of modulating SMYD3 for treatment of cancer
Infobox
Is a
Current assignee
Patent jurisdiction
Patent number
07968281
Date of patent
June 28, 2011
Patent application number
11912860
Date Filed
June 23, 2006
Patent primary examiner
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