Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Xin-Min Wang0
Kathrin U. Jansen0
Loren D. Schultz0
Michelle K. Brownlow0
Janine T. Bryan0
Date of Patent
July 12, 2011
Patent Application Number
12321797
Date Filed
January 26, 2009
Patent Primary Examiner
Patent abstract
Synthetic DNA molecules encoding the HPV58 L1 protein are provided. Specifically, the present invention provides polynucleotides encoding HPV58 L1 protein, wherein said polynucleotides are codon-optimized for high level expression in a yeast cell. The synthetic molecules may be used to produce HPV58 virus-like particles (VLPs), and to produce vaccines and pharmaceutical compositions comprising the HPV58 VLPs. The vaccines of the present invention provide effective immunoprophylaxis against papillomavirus infection through neutralizing antibody and cell-mediated immunity and are also useful for treatment of existing HPV infections.
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