A valve drive device for an engine include a valve for opening or closing an opening of a port to a combustion chamber, a valve drive member for opening or closing the valve and a drive shaft for driving the valve drive member. The device also includes a variable valve timing mechanism for continuously changing a working angle of the valve corresponding to an operation state of the engine by changing a state of drive force transmission from the drive shaft to the valve drive member. A variable valve clearance mechanism is configured such that a valve clearance that is defined as a gap between the valve and the valve drive member can be set at a first value during a first condition in which the working angle of the valve is large to a second different value during a second condition in which the working angle of the valve is small.