Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Eric J. Benjamin0
Ye Edward Tian0
Robert Rothlein0
Adnan M. M. Mjalli0
Jeffrey C. Webster0
Date of Patent
July 19, 2011
Patent Application Number
11789637
Date Filed
April 25, 2007
Patent Primary Examiner
Patent abstract
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.
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