A mobile All Hazards Receipt Facility (AHRF) is provided in an enclosure suitable for mounting on a base vehicle such as a semi-trailer. The AHRF includes a containment area compliant with BSL-3 standards, a containment area compliant with BSL-2 standards, a unique bleaching/decontamination station having an airlock to the outside for receiving incoming sample containers, a class III Biosafety Cabinet (Glovebox) connected to the bleaching station via an airlock through which samples are passed for processing, a biosafety cabinet as well as an onboard air handling system that provides air conditioning, filtration and exhaust and maintains appropriate BSL-2 and BSL-3 air pressure differentials.