US Patent 7992424 Analytical instrumentation and sample analysis methods

Sample introduction components of analytical instruments are provided that can include a membrane inlet component in fluid communication with both a mass analyzer component and a sample inlet. The components can also include a valve in fluid communication with the sample inlet and a sampling component. Components can include a sample loop assembly in fluid communication with valve, and a preconcentration assembly in fluid communication with the valve. Sample analysis methods are provided that can include providing sample to a membrane in fluid communication with a mass analyzer to acquire sample parameter data, and providing the sample to a sampling assembly upon acquisition of predefined sample parameter data. Methods can also include providing sample to a first sampling assembly in fluid communication with a detection component to acquire sample parameter data, providing the sample to a second sampling assembly upon acquisition of predefined sample parameter data.