Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Yuichi Hirata0
Kiyotaka Nakano0
Masayuki Tsuchiya0
Tetsuro Orita0
Hiroyuki Tsunoda0
Date of Patent
August 9, 2011
0Patent Application Number
105515040
Date Filed
December 10, 2004
0Patent Primary Examiner
Patent abstract
Anti-human Mpl antibodies were isolated and purified. Anti-human Mpl diabodies and anti-human Mpl sc(Fv)2 were prepared using genetic engineering techniques and anti-human Mpl sc(Fv)2 was also humanized. The diabodies and sc(Fv)2 were assayed for TPO-like agonistic activity, and were found to have activities higher than those of anti-human Mpl antibodies, or activities equivalent to or higher than those of naturally-occurring human TPO ligand.
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