A retractable syringe includes a barrel, a collar mounted to the barrel, a retraction spring and a needle mount. The plunger includes a first plunger member and a second plunger member that are releasably coupled to initially compress the spring. The second plunger member further includes a seal to prevent fluid leakage between plunger and barrel. After depression of the plunger to deliver the syringe fluid contents, the first plunger member engages the needle mount with needle attached thereto and is rotatably uncoupled from the second plunger member to allow decompression of the retraction spring, which forces retraction of the first plunger member, needle mount and needle engaged therewith. The first plunger member and the collar include elements that co-operatively disable subsequent depression or withdrawal of the plunger. Following retraction of the first plunger member, the second plunger member and seal prevent refilling and re-use of the syringe.