US Patent 8003330 Error-free amplification of DNA for clonal sequencing
Patent 8003330 was granted and assigned to Pacific Biosciences on August, 2011 by the United States Patent and Trademark Office.
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Provided are methods of producing low copy number circularized nucleic acid variants that can be distributed to reaction volumes. The methods include providing a template nucleic acid; producing a population of clonal nucleic acids from the template nucleic acid; generating a set of partially overlapping nucleic acid fragments from the population of clonal nucleic acids; circularizing the partially overlapping nucleic acid fragments to produce circularized nucleic acid variants; and aliquotting the circularized nucleic acid variants into reaction volumes. Related compositions of nucleic acid templates are also provided.
US Patent 08003330 Error-free amplification of DNA for clonal sequencing US Patent 8003330 Error-free amplification of DNA for clonal sequencing
US Patent 08003330 Error-free amplification of DNA for clonal sequencing
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