US Patent 8003634 Analogs of benzoquinone-containing ansamycins and methods of use thereof

Patent 8003634 was granted and assigned to Infinity Pharmaceuticals on August, 2011 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Current Assignee

Infinity Pharmaceuticals

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

8003634

Patent Inventor Names

James R. Porter0

Louis Grenier0

Julian Adams0

Yun Gao0

Roger H. Pak0

Asimina T. Georges Evangelinos0

James L. Wright0

Date of Patent

August 23, 2011

Patent Application Number

12899187

Date Filed

October 6, 2010

Patent Primary Examiner

‌

Bruck Kifle

Patent abstract

The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

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