Patent 8008499 was granted and assigned to Cornerstone Therapeutics on August, 2011 by the United States Patent and Trademark Office.
Disclosed are novel anabaseine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.