Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Stephen Martin Courtney0
Vincent Jacob Kalish0
Andrew D. Cohen0
Frederick Arthur Brookfield0
John P. Toscano0
Lisa Marie Frost0
Date of Patent
October 4, 2011
0Patent Application Number
117247920
Date Filed
March 16, 2007
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
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