A wash basin drain structure includes a tightening assembly, a control rod assembly, a drain pipe, and a plug. A threaded top ring of the fastening assembly relative to a threaded annular seat is screwed reversely to push an anti-leakage washer of the drain pipe upward, so that the threaded top ring and a washer are against the bottom of the wash basin and resilient portions of the resilient ring engages with a non-slip portion of the drain pipe. When a threaded fixing member in a threaded hole of a fixing seat of the control rod assembly is screwed inward, the end of the threaded fixing member will hold against the body of the drain pipe and pull an inner pipe portion of the fixing seat to seal and engage with an insertion hole of the drain pipe. A magnetic end head of a link rod of the control rod assembly is attracted to connect with a magnetic portion of a plug body of the plug to act as a lever. The present invention can be assembled with ease.