Systems and methods are described for configuring several modules each individually small enough to pass through a digestive tract; and a tether or other means for releasably configuring at least the several modules in a group. Such a tether may (directly or indirectly) couple some of the modules via at least a gap in another module from which the tether may slip free, in some embodiments. Such methods may include modes of administering a medication or otherwise taking an action in response to the one or more phenomena.