A pet grooming comb includes a grip having a plurality of first coupling portions circularly arranged around a longitudinal axis thereof and a comb head having a plurality of teeth and a second coupling portion selectively coupled to one of the first coupling portions. Thus, a user can adjust a setting angle of the comb head relative to the grip by means of the engagement of one of the first coupling portions of the grip with the second coupling portion of the comb head, thereby enhancing convenience of use.