A transdermal drug delivery system (100) for providing controlled doses of a drug through the skin of a human or other animal is disclosed. In one embodiment, the transdermal drug delivery system (100) includes a substrate (110) designed to adhere to skin and a transdermal injector array (140) coupled to the substrate (110). The transdermal array (140) has one or more transdermal injectors (210, 220, 230) embedded within including a first transdermal injector (210) configured to administer or provide a first substance to the skin at a speed great enough to produce an appreciable breach in the surface of the skin.