Patent 8071370 was granted and assigned to Sangamo Biosciences Inc. on December, 2011 by the United States Patent and Trademark Office.
Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.