Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Francesca Levi-Schaffer0
Alessandro Moretta0
Ariel Munitz0
Ido Bachelet0
Lorenzo Moretta0
Date of Patent
March 13, 2012
0Patent Application Number
105949260
Date Filed
March 30, 2005
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Disclosed are bi-specific complexes aimed at inhibiting mast cells, eosinophils and/or basophils, and thus, at inhibiting allergy-type reactions. In particular, said complexes are best exemplified by bi-specific antibodies, which bind to two targets present in the same cell. One target is the inhibitory receptor IRp60. The second target is a cell-specific activator, e.g. IgE, cKIT, FcεRI, IL5R or CCR3. Binding of the bi-specific antibody to its targets results in the induction of an inhibitory pathway, through the inhibition of the signaling from the activator. Compositions and uses of the bi-specific complexes are also described.
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