Open roof construction for a vehicle comprising a roof opening defined in a stationary roof part and a movable panel. A slide is movable along a stationary slide guide and is provided with panel engagement elements cooperating with slide engagement elements of the movable panel. A movement of the slide is capable of generating a tilting and/or sliding movement of the panel. The panel engagement elements of the slide comprise two curves and the slide engagement elements of the panel comprise two cams, each for cooperation with a respective one of the curves. Moving the slide in a first direction a cooperation between a first curve and corresponding first cam will lead to lowering a first transversal edge of the panel followed by translating the panel along with the slide. Moving the slide in an opposite second direction a cooperation between the second curve and corresponding second cam will lead to lifting said first transversal edge.