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US Patent 8142784 Antibody-drug conjugates and methods

Patent 8142784 was granted and assigned to Genentech on March, 2012 by the United States Patent and Trademark Office.

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Current Assignee

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Paul Polakis0

Allen J. Ebens, Jr.0

Frederic S. Jacobson0

Mark X. Sliwkowski0

Ralph H. Schwall0

Susan D. Spencer0

Date of Patent

March 27, 2012

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Patent Application Number

123267210

Date Filed

December 2, 2008

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Patent Citations Received

US Patent 12006356 Anti-CCT5 binding molecules and chimeric antigen receptors comprising the same

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US Patent 11759527 Anti-EGFR antibody-drug conjugates

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US Patent 12016842 Methods of using anti-CD79b immunoconjugates

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US Patent 12110341 Composition comprising antibody that binds to domain II of HER2 and acidic variants thereof

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US Patent 11760809 Human monoclonal antibodies to ganglioside GD2

US Patent 11866496 Humanized anti-CD79B antibodies and immunoconjugates and methods of use

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US Patent 11944689 Drug conjugates with self-stabilizing linkers having improved physiochemical properties

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Patent Primary Examiner

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Patent abstract

The present invention relates to antibody-drug conjugate compounds of Formula I:Ab-(L-D)p Iwhere one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.

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