Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
C. Geoffrey Davis0
Douglas Charles Hanson0
Eileen Elliott Mueller0
Jeffrey Herbert Hanke0
Jose Ramon Corvalan0
Mark Joseph Neveu0
Steven Christopher Gilman0
Date of Patent
March 27, 2012
0Patent Application Number
119818240
Date Filed
October 31, 2007
0Patent Citations Received
Patent Primary Examiner
Patent abstract
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucleotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.
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