Is a
Patent attributes
Current Assignee
0
Patent Jurisdiction
Patent Number
Patent Inventor Names
Sean Stevens0
Tammy T. Huang0
Ashique Rafique0
Eric Smith0
Gang Chen0
James P. Fandl0
Jeanette L. Fairhurst0
Joel H. Martin0
...
Date of Patent
May 22, 2012
0Patent Application Number
132300810
Date Filed
September 12, 2011
0Patent Citations Received
Patent Primary Examiner
Patent abstract
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
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