Patent 8188261 was granted and assigned to Idera Pharmaceuticals on May, 2012 by the United States Patent and Trademark Office.
The invention relates to the therapeutic use of novel stabilized oligoribonucleotides as immune modulatory agents for immune therapy applications. Specifically, the invention provides novel RNA-based oligoribonucleotides with improved nuclease and RNase stability and that have immune modulatory activity through TLR7 and/or TLR8.