Embodiments include antenna tuning systems and methods of tuning an antenna of a wireless device with an antenna, a circuit with at least one tunable component, and a processing system. The processing system determines tuning selection inputs during a communication session. Based on the tuning selection inputs, the processing system determines one or more component values for one or more tunable components. In an embodiment, the component value(s) are determined from a set of pre-defined component values. The tunable component(s) are controlled to have the determined component value(s). The circuit may be an impedance matching circuit that includes at least one tunable reactive component. Alternatively, the circuit may be an antenna tuning circuit that includes at least one variable component. In an embodiment, both an impedance matching circuit and an antenna tuning circuit may be implemented, with each type of circuit having one or more tunable components.