Patent 8207177 was granted and assigned to Millennium Pharmaceuticals on June, 2012 by the United States Patent and Trademark Office.
This invention relates to compounds that inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.